Thank you to anyone who has already donated - your generous donations helped make three months of treatment possible.

My brother Nate continues to fight stage IV Hodgkin's lymphoma. He's just 31, with a wife and baby girl. They have no active income (since he's been unable to return to work), no insurance, and cannot afford the treatment he needs. Nate and his family need your help. Please consider a donation, every dollar helps. Thanks.


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#!/usr/bin/env ruby

require 'pp'
require 'inline'

class Scan
  def initialize(seq)
    @seq = seq
  end

  inline do |builder|
    builder.prefix %{
      #define MATCH(A,B) ((equal[A] & equal[B]) != 0)
    }

    builder.prefix %{
      int equal[256] = {
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
          0, 1,14, 4,11, 0, 0, 8, 7, 0, 0,10, 0, 5,15, 0,
          0, 0, 9,12, 2, 2,13, 3, 0, 6, 0, 0, 0, 0, 0, 0,
          0, 1,14, 4,11, 0, 0, 8, 7, 0, 0,10, 0, 5,15, 0,
          0, 0, 9,12, 2, 2,13, 3, 0, 6, 0, 0, 0, 0, 0, 0,
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0,
          0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0
      };
    }

    # ss is the start of the string, used only for reporting the match endpoints.
    builder.c %{
      int backtrack(char* ss, char* s, char* p, int mm, int ins, int del)
      {
          int r = 0;

          while (*s && MATCH(*s, *p)) ++s, ++p;    // OK to always match longest segment

          if (!*p)
              return (s - ss) - 1;
          else
          {
              if (mm && *s && *p && (r = backtrack(ss, s + 1, p + 1, mm - 1, ins, del))) return r;
              if (ins && *s &&      (r = backtrack(ss, s + 1, p, mm, ins - 1, del)))     return r;
              if (del && *p &&      (r = backtrack(ss, s, p + 1, mm, ins, del - 1)))     return r;
          }

          return 0;
      }
    }
 
    # Find all occurrences of p starting at any position in s, with at most
    # mm mismatches, ins insertions and del deletions.
    builder.c %{
      int patscan(char* p, int mm, int ins, int del)
      {
          char* s = StringValuePtr(rb_iv_get(self, "@seq"));
          char* ss;
          int   end;

          for (ss = s; *s; ++s)
          {
              end = backtrack(ss, s, p, mm, ins, del);

              if (end)
                 return end;
          }
       }
    }
  end
end


seq = "tcatcgagtcatcgatcgatcgatcgatcga"
pat = "gtcatcga"

scanner = Scan.new(seq)

puts scanner.patscan(pat, 0, 0, 0)


__END__